We herewith report a case of nevus comedonicus distributed only over the left half of the body along the Blaschko′s lines and not associated with any systemic abnormalities. They represent lines of division of the two cell lines within the embryonic skin tissue. The original description by Blaschko referred to a system of lines on the human skin which the linear naevi and dermatoses follow. In our case, the cytogenetic analysis on. CHARGE stands for coloboma, heart defect, atresia choanae (also known as choanal atresia), restricted growth and development, genital. Lines of Blaschko doi: 10. Some congenital or acquired dermatoses, either inherited or sporadic, have a linear distribution following the embryonic lines described in 1901 by A. It is particularly common in children and rarely seen in adults. Seventeen cases of childhood discoid lupus erythematosus (DLE) have been previously reported in the literature. , BMC Medical Genetics , 2011 ) Mutations involving color-producing cells can lead to pigmentary mosaicism presenting as streaks and swirls following Blaschko lines. Unlike. On comparing the overlays of all body and head lesions with the original lines of Blaschko there was an excellent correlation. The skin abnormalities that define each stage occur along lines of embryonic and fetal skin development known as Blaschko lines (see Figure 3). Blaschko’s lines are unique. The BL were described and drawn by Alfred Blaschko, a German dermatologist, in 1858-1922 [ 1, 2 ]. Not the first to mention it but yeah Blaschko's lines aren't visible to anything normally. We do however hope that visitors to this site can contact us regarding comments that are considered. . A postzygotic mutational event may lead. Approximately 10% of patients with LP manifest nail lesions. LAM coinciding with localized linear scleroderma was diagnosed and is described as hyperpigmentation of the basal layer without the involvement of the dermis and subcutaneous tissue. He noticed that some of his patients had skin disorders that followed a specific. These lines are invisible under normal conditions. Notably, this is distinct from fine and whorled Blaschko's lines (Blaschko, 1901; Happle et al. This condition is an inflammatory skin condition resembling dermatitis or eczema and presents with dry, red irritable skin lesions. Blaschko lines correspond with cell migration or growth pathways that are established during embryogenesis. He noticed that some of his patients had skin disorders that followed a specific. The lines of Blaschko describe a linear pattern of distribution of various congenital, nevoid, and acquired skin disorders with their suspected embryological origins not yet well understood. French dermatologists Gourgerot and Carteaud first described confluent and reticulated papillomatosis in 1927 [1]. These lines are invisible under normal conditions. The lines of Blaschko form a "V" shape over the spine, "S" shapes over the lateral and anterior aspects of the trunk, and a linear pattern over the extremities. Over the course of years of examining thousands of patients, he often observed people who exhibited unusual patterns of dark stripes and swirls that encompassed their entire bodies. Alfred Blaschko is credited with the first demonstration of these lines in 1901. Linear and whorled nevoid hypermelanosis was first described as a distinctive entity in 1988 by Kalter [ 1 ], and to date, approximately 40 patients. . HISTORICAL OVERVIEW. Epidermal nevi occur in one out of 1,000 live births, and 80 percent of cases appear in the first year of life. To our knowledge, the dermatoscopic features of pigmented lesions in LWNH have not been described previously. " While true (if overly simplistic) I can see how it might be a little unclear. Blaschko’s Lines. Cutaneous conditions can follow Blaschko's lines on the skin, which are thought to reflect patterns of cell migration and clonal expansion during embryonic development of the epidermis. Articles were analyzed in which brain imaging methods were used in IP patients with CNS anomalies. Conclusion: Invisible Lines, Visible Impact. We also include cutaneous disorders that have a linear distribution but do not follow Blaschko's lines. They are present, yet not visible, all over the body; Acquired. As its name would suggest, the skin lesions occur along Blaschko lines. Swirling patterns around the trunk and linear patterns down the legs and arms are referred to as Blaschko's lines; Lesions first appear as small 0. Blaschko's lines were firstly described by Alfred Blaschko in 1910. genital and are arranged in a linear fashion following Blaschko’s lines. 2). Background: Lichen planus (LP) with distribution of lesions along Blaschko's lines is a rare entity, accounting for 0. 2Atrophic, squamous, and erythemato-violaceous plaques following Blaschko’s lines were noted on her left knee . The main differential diagnoses are the other linear dermatoses that run along Blaschko's lines, especially an inflammatory linear verrucous epidermal naevus (ILVEN), however, when compared to lichen striatus, ILVEN have the following characteristics: 75% of lesions arise during the first five years of life, most often in the first six months Blaschko lines are distinctive whorled and linear patterns on the skin first described by the dermatologist Alfred Blaschko in 1901. bla·sé (blä-zā′) adj. Preliminary results support the ideas that (1) Blaschko's lines represent single clones of epidermal cells; (2) in patients with HI and severe neurological involvement mosaicism, if detectable, is best shown in keratinocytes; and (3) the cytogenetic defect in epidermis may be directly responsible for the failure of pigmentation in HI. Streaks of hypopigmentation or hyperpigmentation along the lines of Blaschko have been named hypomelanosis of Ito (HI) and linear and whorled nevoid hypermelanosis (LWNH) []. This concept was first introduced by the German dermatologist Alfred Blaschko at the 7 th Congress of German Dermatological Society in 1901. It is not present at birth, hence the term 'acquired'. Lupus panniculitis of the scalp (LPS) is a rare presentation of lupus erythematosus panniculitis (LEP), an inflammatory disorder of the subcutaneous fat, mostly found in 1–3% of patients with lupus erythematosus 1 LPS has the distinctive clinical feature of distribution along the lines of Blaschko, giving rise to linear, arched or annular alopecia. Multiple lesions arise in a linear fashion along the lines of Blaschko, most commonly along a limb or one side of the trunk or head and neck ; Disseminated superficial actinic porokeratosis (DSAP) This is the most common variety and arises in. Conditions of the human integumentary system. Nails of the left hand were also affected (Fig. Blaschko’s lines, also called the Lines of Blaschko, named after Alfred Blaschko, are lines of normal cell development in the skin. They do not correspond to dermatomes, cranial nerve distribution, skin cleavage lines (Langer lines), skin tension lines, embryonic clefts, the lines of lymphatic drainage or blood supply, or hair tracts. The conductor of Blaschko represent ampere pattern assumed by multiple different nevoid and acquired skin diseases on the human. Most of these cases combined features of LP pigmentosus, LP pilaris, and atrophic LP. Achromic naevus. PDF. The cause of lichen striatus is unknown. On the face, Blaschko lines typically run. 62% of all patients. Six archetypical patterns of cutaneous mosaicism can so far be distinguished: (1) lines of Blaschko, (2) checkerboard pattern, (3) phylloid pattern, (4) patchy pattern without midline separation, (5) lateralization pattern, and (6) the sash-like pattern (Figs. Blaschko’s lines, also called the Lines of Blaschko, named after Alfred Blaschko, are lines of normal cell development in the skin. Uninterested because of frequent exposure or indulgence. 7 The majority of LPP. B, Equivalent. Alfred Blaschko in 1901 when he examined over 140 patients with linear skin lesions that followed similar patterns. 24% to 0. [] It is usually unilateral and single, although bilateral or multiple LS have been previously reported in the literature. Correspondence to knownas Blaschko's lines. They may be unilateral in early non-segmental vitiligo, or in segmental vitiligo when confined to part or all of one or more dermatomes or areas delineated by Blaschko's lines. [] However, some cases of LS showing bizarre pattern of distribution. When there is a big difference between the two. Noun [edit] Blaschko's lines pl (plural only) Lines of normal cell development in the skin, which become visible in certain diseases. These stripes, which are known as Blaschko’s lines, were discovered by dermatologist Alfred Blaschko in 1901. Together with new insights on the role for lysosomal signalling in embryonic stem cell differentiation, mutations in the X-linked transcription factor 3 ( TFE3. Blaschko’s lines are invisible lines that are present on healthy skin. These lines are named after Dr. They run down the arms and legs. These lines are invisible under normal conditions. A Case of Segmental Vitiligo Along Blaschko's Lines. Dear Editor, Lichen striatus (LS) is a self-limiting linear dermatosis that predominantly affects children aged 5 months to 15 years and is distributed along the lines of Blaschko. These lines are invisible under normal conditions. Background: The system of Blaschko's lines has been insufficiently documented on the head and neck. The lines of Blaschko represent developmental pathways of ectoderm, and several skin diseases may show Blaschko-linear manifestations, often arising as a result of postzygotic mutations. The lines of Blaschko, which are normally invisible on skin, are thought to follow the paths along which cells migrate as the skin develops before birth. On the trunk and limbs the linear arrangement is usually easily distinguishable, but recognizing that a small lesion on the face follows Blaschko lines can be difficult in some patients (eg, the epidermal nevus represented in Fig 1, A. [] However, some cases of LS showing bizarre. Blaschko. 1,2 There are several terms for this entity, including linear LP, Blaschkolinear LP, and Blaschkoid LP. This concept was first introduced by the German dermatologist Alfred Blaschko at the 7 th Congress of German Dermatological Society in 1901. These lines are invisible under normal conditions. 1016/s0190-9622 (94)70143-1. German dermatologist Alfred Blaschko is credited with the first demonstration of these lines in 1901. Four other patterns of mosaicism are also discussed: blocklike, phylloid, large. Blaschko’s lines. Its constancy in Table 1 Linear dermatoses explained on the basis ofmosaicism. We report two cases of localized, unilateral, linear LP hypertrophicus along the lines of Blaschko. in 1986. The lines of Blaschko represent a pattern followed by many skin disorders. The lines of Blaschko were first described in 1901 by the German dermatologist Alfred Blaschko, who published a book comprising hand drawings of linear lesions of the skin from various parts of the body and a unique collection of 175 patients with epidermal naevi, sebaceous naevi, or naevus angiolipomatosus, as well as acquired. Blaschko's lines, also called the lines of Blaschko, named after German dermatologist Alfred Blaschko, are lines of normal cell development in the skin. However, these lines are invisible in most people. In heterozygous females affected by an X-linked skin disorder, lesions often appear in a characteristic pattern, the so-called Blaschko's lines. Both HI and LWNH encompass heterogeneous groups of disorders characterized by conditions with hypopigmented or hyperpigmented skin. We review the clinical and histologic features of X-linked, congenital/nevoid, and acquired skin diseases that follow these lines. Blaschko’s lines are invisible developmental lines of the skin. Most often diagnosed during infancy because of the striking cutaneous findings that typical follow Blaschko lines. 6%) cases. ”. Case Presentation. These lines are to be distinguished from other linear patterns such as Voight's lines, Langer's lines, and the lines of innervation of the spinal. These lines are invisible under normal conditions. Blaschko线是以首次描述这些线的人名字命名的。. 2021. CDR_112_20. Skin findings of KD are polymorphous, varying from diffuse maculopapular eruptions to psoriasiform lesions. The lines of Blaschko delineate the lines of migration of epidermal cells during embryogenesis. Finally, we differentiate Blaschko's. Dermoscopy of linear dermatosis along Blaschko's line in childhood: Lichen striatus versus inflammatory linear verrucous epidermal nevusThe majority are distributed along the Blaschko line. These distinct types of archetypical arrangement should not. Finally, we differentiate Blaschko's. Most commonly affect the scalp, then the preauricular region, face, and neck. When we start out as a single cell, and then a ball of cells, some of these cells become skin cells. The treatment of linear psoriasis is often challenging, with inadequate response to biological agents reported in the literature. The lines are distinguished from other morphological lines of the skin and do not represent vascular, lymphatic or nervous structures. They were described and drawn by Blaschko 75 years ago. These lines are to be distinguished from other linear patterns, such as Voight's lines, Langer'sBlaschko’s lines, also called the lines of Blaschko, named after German dermatologist Alfred Blaschko, are lines of normal cell development in the skin. All humans have Blaschko’s lines, but they are usually not visible. Multiple organ systems can be involved. Blaschko's lines are the pattern assumed by many different naevoid and acquired skin diseases on the human skin and mucosae. Kawasaki disease (KD) is a self-limited, systemic vasculitis developing in early childhood. These were first described by Alfred Blaschko in 1901. Case Description Patient 1 A 16-year-old Vietnamese male presented with a 1-year history of hair loss of the scalp. The main event which allows the existence of mosaicism is a genetic mutation, either structural or functional. The main purpose of this article is to introduce the concept of Blaschko's lines into the medical, paramedical, and general biological fields of science, and it is hoped that some inter‐reaction can occur between those who regularly see and study other chromosomal and embryological abnormalities. The nevi on the skin can be scattered or densely distributed keratinizing papules, with a small pit in the center. , 1984), not having the complexity of the lines and whorls, but are rather a series of broad linear bands which show a midline dip. These lines may express different amounts of melanin, or become visible due. The archetypal figure has been subsequently updated by others and is represented elsewhere with greater detail in regions such as the head and neck (see Happle and Assim, 2001). The concept of Blaschko’s lines were first introduced by Alfred Blaschko in 1901. Blaschko's lines are the most common pattern of mosaicism. Typically these lines are not visible; however. comedone-like pits coronoid lamellaIn an infant or young child, a nevus sebaceous (sebaceous naevus) presents as a solitary, smooth, yellow-orange hairless patch or plaque, often oval or linear in shape. Early detection of any underlying disease is vital, especially in cases with effective management, because the. Blaschko’s lines are named after Alfred Blaschko, a German dermatologist who first described them in 1901. They become apparent when some diseases of the skin or mucosa manifest themselves according to these patterns. Blaschko’s lines are actually traces of the migration and proliferation of skin cells during embryonic development. They run down the arms and legs and curve around the sides like tiger stripes. 24%-0. A recent study 20 reviewed thousands of photographs of congenital pigmentary disorders or vitiligo and defined the following three major patterns: (1) Blaschko's lines in narrow bands; (2) segmental "quadrilateral shapes"; and (3) nonsegmental "round shapes. The British. 2). . Pigmentary mosaicism refers to patterned hypo- and/or hyperpigmentation that results from genetic heterogeneity of skin cells. Moreover, the clinical and histopathologic overlap between the entities of blaschkitis and lichen striatus is explored. The majority are linear epidermal naevi — they form a line, usually just on one side of the body (unilateral, also known as naevus unis lateralis). Blaschko's lines were firstly described by Alfred Blaschko in 1910. Unlock premium audio pronunciations. Cases with unilateral involvement of upper and lower limbs, chest, back, and waist are even rarer. There have been many reports of congenital and acquired dermatosis that. The LCLE is a highly unusual variation of discoid lupus erythematosus (DLE) []. Paul Blaschko, who first described them in the early 1900s. Background: The system of Blaschko's lines has been insufficiently documented on the head and neck. These lines are only visible in those with a mosaic The lines are believed to trace the migration of embryonic cells. The appearance of LPP in our case could not be directly linked to a specific cause because of the ambiguity in the pathogenesis of the disease. The initial appearance was reddish hyperkeratotic. Type 1b Blaschko lines are so broad that it is sometimes difficult to even identify a linear pattern. A dermatome is an area of skin that is primarily supplied by a single nerve root: communicating sensation from this skin region to the brain. Alfred Blaschko is credited with the first demonstration of these lines in 1901. General mosaicism: Occurs when there are two or more cell lines existing in a baby. Blaschko’s lines are an invisible pattern on the skin that represents the developmental pathways of cells. [2,3] Clinically it should be differentiated from other lesions following the lines of Blaschko, such as incontinentia pigmenti, early epidermal nevi, linear and whorled nevoid. Blaschko’s lines are attributed to the migration lines of epidermal cells during embryogenesis and are characterized by a V-shaped pattern on the posterior midline, S-shape on the abdomen, and spiral on the posterior scalp. An epidermal naevus usually arises on the trunk and limbs and is uncommon on the face or scalp. [] These lines create a surface pattern which is distinct from other. They differ from dermatomes, and appear as single or multiple lines, whorls (swirls) and wave-like shapes in the skin. Human skin is covered in stripes. The most common clinical patterns are streaks and swirls following Blaschko's lines in narrow or broad bands and a block-like distribution. (A) Blaschko lines distributed lesions (2-weeks-old). In the present instance, the linear erythema resolved promptly in response to primary IVIG therapy as with the other KD symptoms, suggesting that its pathogenesis was. The human stripes are visible only under UV light but invisible to th. Although in the initial description 1 extracutaneous findings were not reported, HI was later recognized as a. , incontinentia pigmenti). We also include cutaneous disorders that have a linear distribution but do not follow Blaschko's lines. Cases of LP involving multiple segments of the body along the Blaschko’s lines with nail damage are rare, and the diagnosis was established based on dermoscopy and skin biopsy. They curve around the sides, like tiger stripes. Acquired blaschkoid dermatitis is unilateral — it only affects one side of the body. In 1901, the German dermatologist Alfred Blaschko described a system of cutaneous lines that represented the typical pattern that linear nevi appeared to follow. JAMA Dermatology ( IF 10. Confluent and reticulated papillomatosis is an uncommon skin condition affecting the trunk, neck and axillae. We review the clinical and histologic features of X-linked, congenital/nevoid, and acquired skin diseases that follow these lines. ”. Blaschko’s lines don’t affect the body. Four other patterns of mosaicism are also discussed: blocklike, phylloid, large patches. The lines of Blaschko delineate the lines of migration of epidermal cells during embryogenesis. Incontinentia pigmenti (IP; Bloch-Sulzberger syndrome, MIM #308300) is an X-linked dominant genodermatosis that is usually lethal in males before birth [ 1-4 ]. A literature review by Kabbash and associates 1 found that 11. They follow a “V” shape over the back,. However, in the case of skin diseases, they develop skin lesions or eruptions such as warts. BACKGROUND Linear atrophoderma of Moulin (LAM) is a dermatosis that affects children and adolescents characterized by hyperpigmented and atrophic. After Happle’s viewpoint 2 in Chuong et al. Although LP is a common mucocutaneous condition, LP in a Blaschkoid distribution is a rare variant, estimated to affect 0. 线状苔藓是获得性、炎症性皮肤病，呈自限性，皮损线状排列，无其他症状，主要发生于儿童，一般单侧发疹，最常累及四肢，沿Blaschko线连续性或间断性分布。. Blaschko’s lines were originally described by Dr. Linear LP lesions are unilateral and distributed along Blaschko lines [4], [5]. It's probably still somewhat confusing, but articles on rare and little-understood medical conditions. It is not present at birth, hence the term 'acquired'. Blaschko's lines, also called the Lines of Blaschko, are an extremely rare and unexplained phenomenon of human anatomy first presented in 1901 by German dermatologist Alfred Blaschko. Lichen sclerosus along Blaschko's lines on left chest. The stripes on humans are called Blaschko’s lines,. Epidermal FIGURE 1 Clinical features and histopathological findings. . Some patterns were restricted to. Blaschko’s lines are only visible to those who have a mosaic skin condition or are a chimera. Follows Blaschko’s lines; Streaks and whorls; Fades in adolescence; The third incontinentia pigmenti stage is the hyperpigmented stage in which the skin is darkened in a swirled pattern often described as a “marble cake” appearance. Different descriptive terms for these disorders include "linear and whorled nevoid hypermelanosis" (LWNH), [1] "progressive cribriform and zosteriform. it's like trying to make a Neapolitan ice cream but with three things of vanilla instead of each flavor. They were described and drawn by Blaschko 75 years ago. 5 It has been postulated that the cells along Blaschko lines contain distinct genotypes that may ultimately permit a unique response to stimuli such as. The histopathologic analysis of a skin biopsy in conjunction with the anamnesis allowed the diagnosis of. and mucous membranes. Fig. A biopsy specimen showed a thinned epidermis devoid of rete ridges and vacuolar degeneration of the basal layer. Lines of Blaschko are usually invisible unless genetic mutations result in mosaicism that alters the pigmentation, proliferation, and/or differentiation of epidermal cells. Several examples of chekerboard or patch patterns on human skin are seen in several human diseases (Happle, 1995, 2004). Conclusions: Our data indicate that linear morphoea follows the lines of Blaschko. Blaschko’s lines, also called the lines of Blaschko, named after Alfred Blaschko, are lines of normal cell development in the skin. These lines are to be distinguished from other linear patterns such as Voight's lines, Langer's lines, and the lines of innervation of the spinal nerves. These lines are. The lines of Blaschko are a pattern of lines on the skin that represent the developmental growth pattern during epidermal cell migration. Clinical features are heterogeneous. Blaschko's lines are the pattern assumed by many different naevoid and acquired skin diseases on the human skin and mucosae. Human skin is overlaid with what dermatologists call Blaschko’s Lines, a pattern of stripes covering the body from head to toe. Jun 21, 2020 - Blaschko lines - Are humans striped? It looks they are and it is called Blaschko lines. 10. Blaschko's lines were delineated in 1901 by a German dermatologist Alfred Blaschko . The objective of this study was to consider a hypothesis of the existence of Blaschko lines in the CNS in the example of incontinentia pigmenti (IP). It is solitary in 50% of cases and may follow Blaschko lines. Each patch of linear psoriasis represents one cell and all of the copies that it made. Line of Blaschko. She had no other. Objective: The aim of the study was to elaborate this pattern in a comprehensive way. Numerous skin conditions, including genodermatoses, nevi, and inflammatory disorders can present along Blaschko lines. Incontinentia pigmenti, also known as Bloch-Sulzberger syndrome, is an uncommon sex-linked inherited syndrome reported primarily in females, as it is often lethal to male fetuses in utero. They are often more visible. Blaschko’s lines are a pattern of lines, swirls, and curves on the skin that typically follow geometric shapes like diamonds and ovals and form a V- or S-shaped pattern. Blaschko's lines are the most common pattern of mosaicism. We review the clinical and histologic features of X-linked, congenital/nevoid, and acquired skin diseases that follow these lines. All humans have Blaschko’s lines, but they are usually not visible. Background: The system of Blaschko's lines has been insufficiently documented on the head and neck. Method: One hundred eighty-six figures showing skin lesions following Blaschko's lines on the head and neck were collected from literature and patient files,. The eruption is. A skin condition, also known as cutaneous condition, is any medical condition that affects the integumentary system—the organ system that encloses the body and includes skin, nails, and related muscle and glands. The two. Blaschko's lines. [2,3] In contrast to dermatomes, Blaschko's lines form a V-shape over the spine and an S-shape on the lateral and anterior aspects of the trunk. Nevertheless, this should be considered in the differential diagnosis of any macular hyperpigmentation. Cutaneous mosaicisms usually manifest by specific patterns on the skin and the archetypic pattern is the system of Blaschko lines, but others include checkerboard, phylloid, large patches without midline separation and lateralization. in 1993. The eruption is typically unilateral, most often involving the extremities, and follows the lines of Blaschko in a continuous or interrupted pattern. Hypopigmentation along Blaschko’s lines defines hypomelanosis of Ito (HI). Blaschko lines - Are humans striped? It looks they are and it is called Blaschko lines. It depends on their location. Lichen striatus (LS) is uncommon and occurs most frequently in children. 24%-0. The lines of Blaschko represent an pattern accepted by many different nevoid and acquired skin diseases on the human skin and mucosae and do not correspond to any know nervous, vesicular or lymphatic structures. BACKGROUND Lichen planus (LP) with distribution of lesions along Blaschko’s lines is a rare entity, accounting for 0. According to this result, the linear hypomelanotic lesions along Blaschko's lines in HI may develop as a consequence of mosaicism of epidermal cells. were the first to describe a seemingly unidentified entity characterized by the presence of hyperpigmented and atrophic band-like lesions that closely followed Blaschko’s lines []. Parental. A diagnosis of scalp mosaicism associated with widespread cutaneous mosaicism due to systematized sebaceous nevus was made. As these cells divide and spread over the growing body, they form swirls and streams that create the lines of Blaschko. Here, we report a case of this rare disorder and have put forward an argument why. Blaschko lines correspond to the path of embryonic cells as they grow outward from the dorsal midline toward the ventral. Four other patterns of mosaicism are also discussed: blocklike, phylloid, large patches. Blaschko’s lines. This contribution reviews the clinicopathologic spectrum of skin lesions that follow Blaschko lines. Blaschko’s lines are actually traces of the migration and proliferation of skin cells during embryonic development. This contribution provides an update on the diverse genetic etiologies. Lichen striatus is an acquired, asymptomatic, and self-limited linear inflammatory skin disorder that predominantly affects children [ 1,2 ]. TLDR. Females with X-inactivation and skin pigment differences will show it under UV light. Linear and whorled nevoid hypermelanosis (LWNH) is a pigmentation disorder characterized by macular hyperpigmentation following the lines of Blaschko. TIL Human skin is overlaid with Blaschko’s Lines, a pattern of stripes covering the body from head to toe, invisible unless under UV light or if certain skin conditions manifest them mentalfloss. They do not follow neural, vascular, or lymphatic structures and are distinct from dermatomes as well as Langer′s lines. Cutaneous mosaicisms usually manifest by specific patterns on the skin and the archetypic pattern is the system of Blaschko lines, but others include checkerboard, phylloid, large patches without midline separation and lateralization. Net Letter Nevus comedonicus along Blaschko’s lines Sir, groups of dilated follicular openings filled with black, Nevus comedonicus is an uncommon skin abnormality hard plugs, distributed over left cheek, left arm and first described in 1895 by Kofmann who used the term forearm, left side of the chest [Figure 1], abdomen, left “comedo-nevus”. It is classified into two major types, segmental and non-segmental, with the latter including several subtypes (generalized vitiligo, acrofacial vitiligo, and. Treatment with 2% topical minoxidil twice a day produced gradual elongation and thickening of the affected hairs with considerable cosmetic. 4 The pattern is attributed to lines of migration of epidermal cells during embrogenesis. Here we report a case of an 11-year-old female child presented with multiple hyperpigmented and hyperkeratotic papules present over the posterior aspect of right lower extremities along Blaschko’s lines. 1976. (1987) reported 2 unrelated Japanese children with early-onset reticulate hyperpigmentation distributed in a zosteriform pattern along the lines of Blaschko on the trunk and limbs, but sparing the face, palms, and soles. Blaschko's lines are the pattern assumed by different naevoid and acquired skin diseases on the human skin . They follow a “V” shape over the back,. They. thought to represent pathways of epidermal cell migration and proliferation during the development of the fetus; become apparent when some diseases of the skin or mucosa manifest themselves according to these patterns Blaschko’s lines (BL) are considered systematized cutaneous developmental patterns during embryogenesis that are different from vascular, neural, or lymphatic pathways. Four other patterns of mosaicism are also di. 7. Blaschko’s lines are embryonal, epidermal cell lines distinct from the dermatome, and cutaneous lesions following Blaschko’s lines are a manifestation of cutaneous mosaicism [5]. in 1998 to reflect the linear nature of the diseaseTo date, there have been 16 documented cases of linear alopecia diagnosed as chronic cutaneous lupus erythematosus occurring in a linear configuration following Blaschko's lines. Out of the 3 reported cases of linear LSA that appeared on the face, one case showed facial lesion following the Blaschko's line without any oral mucosal lesion, and the other 2 cases showed additional oral mucosal. These lines are to be distinguished from other linear patterns such as Voight's lines, Langer's lines, and the lines of innervation of the spinal nerves. Lichen striatus is a self-limited lichenoid eruption that follows Blaschko’s lines. Unilateral LPP with a Blaschko’s line is a unique condition. A. When six-months-old, there were Blaschko linear,. IP is caused by loss-of-function mutations in the IKBKG (inhibitor of kappa light polypeptide gene enhancer in B cells, kinase gamma) gene, formerly known as NEMO (nuclear factor. Mosaicism describes an individual composed of two or more genetically. However, these lines can become visible if a person is suffering from a skin disease. The lines of Blaschko represent a classic pattern of cutaneous mosaicism that can be observed in a wide variety of congenital and acquired skin disorders. have described linear and zosteriform lesions that were lateralized to the right side of the body along the lines of Blaschko. Numerous skin conditions, including genodermatoses, nevi, and inflammatory disorders can. He noticed that some of his patients had skin disorders that followed a specific. Herein, we report a patient with patterned cutaneous hypopigmentation with a similar phenotype due to a novel. 3 The term “linear cutaneous lupus ery-thematosus” was later proposed by Abe et al. The eruption affects the lines of Blaschko, which are thought to be embryonic in origin. 1. Blaschko's lines, also called the lines of Blaschko, are lines of normal cell development in the skin. There have been many attempts to elucidate the Blaschko's lines on face from the distributional patterns of different nevi, but studies that evaluated exclusively pigmentary nevi are sparse. Blaschko, in 1901,. To the best of our knowledge, a similar clinical presentation has been. Oral antibiotic therapy is the mainstay of treatment. It is characterised by skin abnormalities in the form of unilateral or bilateral cutaneous macular hypopigmented whorls, streaks and patches, corresponding to Blaschko’s lines. Blaschko lines are consistently V-shaped on the upper spine, S-shaped on the abdomen, inverted U-shaped from the breast area to the upper arm, and perpendicular down the front and back of the lower extremities. Although cases of lichen planus (LP) are not uncommon, LP with lesion distribution along the Blaschko’s lines is a rare entity, accounting for only 0. Lines similar to ‘Blaschko's lines’ have also been described in eyes and teeth. 9 ) Pub Date: 2022-02-01 , DOI: 10. Approximately 10% of patients with LP. A case of male patient with adult blaschkitis presenting as unilateral asymptomatic erythematous edematous papules, papulovesicles, and plaques over Blaschko's lines, in which skin biopsy revealed coexistent pathological features of lichen striatus and adult blaschkitis along with blood eosinophilia, has been presented here. Blaschko's lines, also called the lines of Blaschko, are lines of normal cell development in the skin. Nevertheless, this should be considered in the differential diagnosis of any macular hyperpigmentation. They were described and drawn by a German dermatologist, Blaschko, more than 100 years ago. The major function of this system is as a barrier against the external environment. ” No conditions following Blaschko's lines in narrow bands had a genetic abnormality. Four other patterns of mosaicism are also discussed: blocklike, phylloid, large. Fig 4 Acne on the back at age 19 years, with scarring more. Blaschko's lines are attributed to the migration lines of epidermal cells during embryogenesis and are characterized by a V-shaped pattern on the posterior midline, S-shape on the abdomen, and. We also include cutaneous disorders that have a linear distribution but do not follow Blaschko's lines. The clinical and histologic characteristics of childhood DLE are discussed and a review of the linear manifestations of childhood LE is. They become. These lines, which are invisible under normal conditions, indicate the normal. Citation 59 On the other hand, blaschkoid LP is differentiated from linear LP, as it adheres to Blaschko’s lines. 1, 2 The nevi are generally unilateral, following Blaschko lines in linear. These lines are to be distinguished from other linear patterns such as Voight's lines, Langer's lines, and the lines of innervation of the spinal nerves. These stripes, which are known as Blaschko’s lines, were discovered by dermatologist Alfred Blaschko in 1901. He recognized the pattern as distinct from dermatomes and Langer lines. What are the features of epidermal naevus? Linear epidermal naevus. The skin abnormalities that define each stage occur along lines of embryonic and fetal skin development known as Blaschko lines (see Figure 3). If occurring on the trunk or extremities, they follow Blaschko lines. Follows lines and swirls called Blaschko lines ; Usually unilateral, but may be bilateral and widespread in severe cases. The lines trace how one cell in a baby divided and grew. Blaschko’s lines are named after Alfred Blaschko, a German dermatologist who first described them in 1901. These lines are only visible in those with a mosaic [1] [2] [3] skin condition or in chimeras where different cell lines contain different genes. We review the clinical and histologic features of X-linked, congenital/nevoid, and acquired skin diseases that follow these lines. On the chest and upper back they rise in a swirl before. We are, in essence, walking mosaics. The system of Blaschko's lines on the head and neck as elaborated by this study is more precise than previously published diagrams and shows definite crossing of lines. In the case of somatic mutations (cutaneous mosaic ), the spread of the affected cell clone is visualized by the corresponding linear hamartoma (nevus). This contribution reviews the clinicopathologic spectrum of skin lesions that follow Blaschko lines. Hypomelanosis of Ito, initially referred to as incontinentia pigmenti achromians, is a rare neurocutaneous disorder. Although in the initial description 1 extracutaneous findings were not reported, HI was later recognized as a. The.